Table 1: Polymeric nanoparticle herbal formulations Liposomes Liposomes are nanoparticulate systems that have been developed since more than four decades for drug delivery to specific site in the body.28 Some properties like amphiphilicity, biocompatibility and biodegradability of liposomes are important for delivery of herbal drugs.
complexes BMT ont été fabriquées en attachant aux BMT (i) des liposomes vides (BMT-LP), (ii) des liposomes contenant un agent anticancéreux SN38 (BMT-LSC), et (iii) des nanoparticules superparamagnétiques de magnétite (BMT-S200). L’efficacité de l'attachement des charges et du
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and they were proposed as a drug delivery nanoparticle plat-form in 1970s . After extensive studies on their funda-mental properties including lipid polymorphisms, lipid-protein and lipid-drug interactions, and mechanisms of liposome disposition in 1980s, the application potential of liposomes as a drug delivery vehicle was thoroughly recog-
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Solid lipid nanoparticle overview For lipid and lipid-based drug delivery systems, phospholipids are an important constituent because of their various proper-ties, such as amphiphilic nature, biocompatibility and multi-functionality. However, liposomes, lipospheres, and microsimulation carrier systems have many drawbacks such as
delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting.
Liposomes have been recognized as carriers for drug delivery. Solid lipid nanoparticles and lipoplex (liposome-polycation-DNA complex), also called lipid nanoparticles, are currently used to deliver drugs and genes to ocular tissues. A solid lipid nanoparticle (SLN) is typically spherical, and possesses a solid lipid core matrix that can
Targeted Drug Delivery with a Spherical Particle: Liposomes, micelles, and surfactant- or polymer-stabilized oil-in-water microemul-sions can all be used to hide drugs inside their structures in the hopes that a judicious choice of surface chemistry will guide the carrier to the site of the disease. If a trigger for releasing the
Pharmaceutical Science Conference, Tehran, Iran 2015. Haeri A, Dadashzadeh S, Sadeghian S, Rabbani S, Anvari MS; Attenuation of neointimal hyperplasia in balloon-injured blood vessels via local delivery of sirolimus-loaded chitosan coated liposomes, Nanomedicine in Diagnosis and Treatment of Hard to Treat Disease Congress, Tehran, Iran 2015.
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delivery system able to transport drug-loaded nanocarriers to inflamed tissue by exploiting the inherent ability of neutrophils to migrate to inflammatory tissue is reported. This hybrid system (neutrophils loaded with liposomes ex vivo) efficiently migrates in vitro following an inflammatory chemokine gradient.
3.2. Lipid drug delivery systems Lipid-based DDS are an accepted, proven, commercially viable strategy to formulate pharmaceuticals for topical, oral, pulmonary or parenteral delivery. Lipid formulations can be tailored to meet a wide range of product requirements. One of the earliest lipid DDS- liposomes have been used to improve drug solubility.
After analysing the linear viscoelastic region for all the liposomal gels, a frequency sweep was performed in order to provide more information on the forces or
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