Head and Neck Squamous Cell Carcinoma: Epigenetic Landscape
to disturbances in gene expression level involved in the cell proliferation, differentiation, apoptosis, angiogenesis and cell motility. Similarly, a higher rate of cancer recurrence and metastases is associated with mutations in NOTCH1-4 genes in HNSCC [15]. Moreover, PI3K-Akt/mTOR constitutes a frequently disturbed pathway in HNSCC and simultane-ously is a cascade responsible for ...
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