Biol 350 – Spring 2010BIOL 350: General Microbiology –Syllabus Spring 2010BIO 350 is an upper division course on Microbial Biology consisting of both lecture and laboratory. Thecourse will cover eukaryotic and prokaryotic microbes and viruses, but will emphasize bacteria. Thiscourse will provide a conceptual and experimental background in microbiology sufficient to enablestudents to take more advanced courses in related fields.Instructors:Office:Email:Lecture:Office hours:Kelly Doran, Ph.D.NLS [email protected] 12:00 – 12:50, HH 221by appointmentScott Kelley, Ph.D.LS [email protected] appointmentPlease Write 350 and your lab section in the subject line of email messages to the instructorStudent Learning OutcomesAt the end of this course you will be able to: Compare and distinguish the basic groups of microbes, including prokaryotic microbes (Archaea,Bacteria), and Viruses, and eukaryotic microbes.Understand the processes needed for one bacterium to become two, and understand the mechanismsinvolved.Compare and contrast major pathways of catabolism, specify the relative energy yield from eachpathway, list the key products of each pathway, and describe biochemical pathways used formicrobial taxonomy.Compare and contrast major pathways of biosynthesis and list the key products of each pathway.Draw a typical microbial growth curve, and predict the effect of different environmental conditionson the curve.Compare and contrast eukaryotic and prokaryotic genomes, and gene expression in each group.Compare and contrast the acquisition of novel genetic information in microbes via mutations andgenetic exchange, specifically conjugation, transformation and transduction,Specify the role of microbes in global C, N, S, and P cycles, and list examples of microbes thatcontribute to key metabolic aspects of these cycles.List different types of symbiotic interactions between microbes and other organisms, includingcommensalism, mutualism, and parasitism, and provide examples of each.Summarize common features of microbial pathogens, with emphasis on bacterial and viralpathogens.Summarize mechanisms of animal defenses to infection, including primary defenses, innateimmunity, and acquired immunity.Compare and contrast beneficial and harmful uses of organisms, including applications inbiotechnology and bioterrorism.Have a solid grasp of the scope of the microbial world and its role in shaping this planet and all itsinhabitants
BIOL 350 Syllabus - Spring 2010Page 2Prerequisites: This course requires that you have taken the following courses (or equivalent) in biologyand molecular biology (BIOL 203, 203L, 204, 204L), chemistry (CHEM 232, 232L), and you havecompleted the lower division writing competency requirement.Website: Notices and supplemental materials will be posted on the BlackBoard n”. Check this website regularly for updates.Textbook: The textbook for this course is Microbiology: An Evolving Science (W. W. Norton, Inc.) byJoan Slonczewski and John Foster. The textbook will be used as a resource for both the lecture and labportions of this course. Pages of the textbook that correlate with the corresponding lecture topics arelisted on the Lecture schedule. Reading the textbook may help you understand and be able to applyconcepts presented in class but, unless specifically noted in class, you will not be tested on topics thatare not discussed in the lecture or lab, or included in handouts or supplements on the course website.Study Space: me.asp. Provides resources to helpyou master the material in your textbook, and earn better grades. This includes access to ProcessAnimations, Study Plans, Summaries, Flashcards, and Diagnostic Quizes. Additionally the textbook isabvailable as an ebook at 2 per chapter.Lecture exams: There will be three exams each worth 100 points. No make-up exams will be given. Ifyou believe a question on your exam was incorrectly graded, you must contact the instructor within oneweek of the day the exam was returned – no considerations will be made after this one week window.Use of cell phones, books, notes, or calculators will not be allowed during exams. The exams willconcentrate on the material covered in lectures, handouts, and assigned readings. Because the lab andlecture are closely related, some concepts from labs can be included in each lecture exam. The examswill be short answer or multiple choice questions, given during the regularly scheduled class times.Exams will be promptly graded and returned. Answers for the exams will be posted on the courseBlackBoard site after the exams are graded. The Final exam will not be returned, but you may make anappointment to peruse your exam if desired.Course grades: Course grades will be based upon a total of 600 points; 300 points for the lecture and300 points for the lab. The distribution of points assigned in the lab is described in the BIOL 350 Labsyllabus. The final grade will be based upon the percentage of total points obtained using the followingscale:
BIOL 350 Syllabus - Spring 2010Page 3Scale:B : 88-89%C : 78-79%D : 68-69%A: 93-100%B: 83-87%C: 73-77%D: 63-67%A-: 90-92%B-: 80-82%C-: 70-72%D-: 60-62%F: 59%The percent cutoff for a grade may be lowered but will not be raised.Class etiquette: Please be considerate of your neighbors and the lecturer. Abstain from distractionssuch as carrying on conversations or entering and exiting during lectures. Cell phones must be turned offduring the lecture and lab. If you must be available for a potential emergency, set your phone to vibrate.Special accommodations: To request disability accommodations, please make an appointment to speakwith the instructor at the beginning of the semester.Studying: How should you study for this course? Go over your lecture notes after each lecture, whilethe material is still fresh on your mind. Although some memorization is invariably necessary whenlearning a new "language", the goal of learning is to understand the information, not to simply memorizea bunch of disconnected "facts". A major purpose of studying is to discover what you don't understandso that you can do something about it. Don't just passively read the notes, think about them and askyourself questions about them. Do you understand what was said? Does it make sense and why?Compare and contrast the new information with things that you have already learned. Some people findstudy groups very helpful for the learning process.Keep up regularly. You can't cram all of the information into your brain the night before an exam, andwe may not be available to answer your questions at the last minute. For this upper division lecture andlaboratory course – you should plan to spend at least 6 hours per week OUTSIDE of class studying forthis course.Use the Norton Microbiology Study /welcome.asp.Taking notes: Attending class regularly and keeping good notes is essential for success in this course.Good notetaking is an acquired skill. Don't try to write full sentences – you will be so busy writing thatyou may miss the next point and your notes will be harder to study. Instead of writing down every wordduring lecture, write down key phrases and use short abbreviations. Some useful abbreviations are listedbelow, and of course you can make up your own. !"!" !w/equals, the same asnot equal to, differentapproximately equal toincreaseddecreasedless thangreater thanchangewithw/o[ ]EAANAbpKbMbenzwithoutconcentrationenergyamino acidnucleic acidbase ndedphage
Biol 350 – Spring 2010Additional Resources:The Microbe blog by Dr. Schaechter’s “Small Things hter/Todar's Online Textbook of Bacteriology: http://www.textbookofbacteriology.net/Enrichment Activities: Consider attending the Microbiology Journal Club Fridays at Noon in the BioScience Center, GoldAuditorium. Consider attending meetings of the San Diego Microbiology Group at Scripps Institute ofOceanography the 3rd Wed of every month at 6 pm (pizza inlcuded).State Budget Cuts Cause Faculty Furloughs:The devastating California state budget cuts prohibit faculty and staff at SDSU from working on twodays per month during the 2009/10 academic year.The faculty furlough prohibits faculty members from teaching, being on campus, doing research, andconsulting with students on two days per month. Furlough days are listed on the schedule. On thosedays, classes and office hours are cancelled and telephone and e-mail messages will not beanswered.To avoid faculty and staff furloughs at SDSU in the future, you may want to contact your legislators inSacramento so that they better understand how cutting the state budget for higher education affects youreducation and your future.
Biology 350 – General MicrobiologySpring 2009LectureDateTopicInstructor1Wed 1/20Course IntroductionDoran2Mon 1/25Microbiology: An Evolving ScienceKelley13Wed 1/27The Bacterial Cell: Structure and Function IDoran2,34Mon 2/1The Bacterial Cell: Structure and Function IIDoran2,35Wed 2/3Bacterial Culture, Growth and DevelopmentDoran4,56Mon 2/8From Genes to ProteinsDoran7,87Wed 2/10Viruses: The BacteriophageDoran68Mon 2/15Mobile Genetic Elements and Gene TransferDoran99Wed 2/17Molecular RegulationDoran10Mon 2/22Exam #110Wed 2/24Furlough Day11Mon 3/1Energy through Respiration and Fermentation IKelley13,1412Wed 3/3Energy through Respiration and Fermentation IIKelley13,1413Mon 3/8BiosynthesisKelley1514Wed 3/10Industrial Microbiology and BiotechnologyKelley1615Mon 3/15Origins and EvolutionKelley1716Wed 3/17Bacterial DiversityKelley1817Mon 3/22The ArchaeaKelley19Wed 3/24Exam #2Mon 3/29Spring RecessWed 3/31Spring RecessMon 4/5EukaryaKelley2018Chapter1
Biology 350 – General MicrobiologySpring 200919Wed 4/7Microbial EcologyKelley2120Mon 4/12Microbes and the Global EnvironmentKelley22Wed 4/14Microbes & HistoryKelley21Mon 4/19Normal FloraKelley2322Wed 4/21Innate ImmunityDoran2323Mon 4/26Microbial PathogenesisDoran2524Wed 4/28Microbial DiseasesDoran2625Mon 5/3Antimicrobial TherapyDoran2726Wed 5/5Course synopsisKelley/Doran27Mon 5/10Furlough DayWed 5/12Exam #32
Textbook: The textbook for this course is Microbiology: An Evolving Science (W. W. Norton, Inc.) by Joan Slonczewski and John Foster. The textbook will be used as a resource for both the lecture and lab portions of this course. Pages of the textbook that correlate with the corresponding lecture topics are listed on the Lecture schedule.