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The dopamine hypothesis of bipolar affective disorder: the ...

The dopamine hypothesis of bipolar affective disorder: the ...

OPEN REVIEW The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment AH Ashok 1,2,3,4, TR Marques , S Jauhar 1,2,3,4, MM Nour1,2,3, GM Goodwin5 ...

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Nucleus Accumbens Dopamine and the Regulation of Effort in ...

Nucleus Accumbens Dopamine and the Regulation of Effort in ...

warrant a detailed and critical examination of the hypothesis that accumbens DA mediates the primary reinforcing or mo-tivating effects of natural stimuli such as food. The results of this examination point to severe deficiencies in the general form of the DA hypothesis of reward (Salamone et al., 1997, 1999; Salamone and Correa, 2002). The suppressive effects of systemic injections of DA ...

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BRAINSTORMS Clinical Neuroscience Update

BRAINSTORMS Clinical Neuroscience Update

Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis: dopamine, serotonin, and glutamate Stephen M. Stahl ISSUE: Psychosis is now widely hypothesized to involve neural networks beyond the classical dopaminergic mesolimbic pathway, including serotonin and glutamate systems as well. Take-Home Points ’ The dopamine hypothesis of psychosis has become a classic ...

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Apomorphine and the dopamine hypothesis of schizophrenia ...

Apomorphine and the dopamine hypothesis of schizophrenia ...

204 Revue de psychiatrie & de neuroscience Vol. 26, no 3, 2001 Introduction The dopamine (DA) hypothesis of schizophrenia, which implicates an enhancement of DA function, was first proposed over 3 decades ago and remains a dom-

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Addiction and its brain science - Wiley Online Library

Addiction and its brain science - Wiley Online Library

of abuse and the mesolimbic dopamine system have addi-tionally furnished a major hypothesis in the neurobiology of addiction, suggesting that irreversible synaptic alter-ations on the molecular and/or structural level (i.e. per-sistent drug-induced synaptic plasticity within the dopaminergic reinforcement system) may underlie addic-tive behavior.

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Learning to Avoid in Older Age - Brown University

Learning to Avoid in Older Age - Brown University

Learning to Avoid in Older Age Michael J. Frank and Lauren Kong University of Arizona The dopamine hypothesis of aging suggests that a monotonic dopaminergic decline accounts for many of the changes found in cognitive aging. The authors tested 44 older adults with a probabilistic selection task sensitive to dopaminergic function and designed to assess relative biases to learn more from ...

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Human Psychopharmacology Vol 16 No 8

Human Psychopharmacology Vol 16 No 8

Depatie L, Lal S*. (2001). *McGill Univ, Douglas Hosp, Dept Psychiat Res Ctr, 6875 Lasalle Blvd, Verdun, Quebec, Canada H4H 1R3. Apomorphine and the dopamine hypothesis of schizo-phrenia: A dilemma? (Review). J Psychiatry Neurosci 26 (3) 203-220 Desai HD et al. (2001). c/o Jann MW, Mercer Univ, Sthn Sch Pharm, Dept Pharm Practice & Pharmaceut Sci, Atlanta, Ga ...

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Dopamine in Schizophrenia

Dopamine in Schizophrenia

The Dopamine Hypothesis of Schizophrenia Schizophrenia is a major mental disorder with about 0.85%–1% lifetime prevalence world wide (Jablensky et al. 1992).The course of schizophrenia is characterized by the onset of clinical symptoms after puberty and a high symptom heterogeneity. Schizophrenia symptoms are considered to fall into two major classes: positive and negative. According to the ...

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Dopamine in Motivational Control: Rewarding, Aversive, and ...

Dopamine in Motivational Control: Rewarding, Aversive, and ...

hypothesis is that dopamine controls synaptic plasticity accord-ing to a modified Hebbian rule that can be roughly stated as ‘‘neurons that fire together wire together, as long as they get a burst of dopamine.’’ In other words, if cell A activates cell B, and cell B causes a behavioral action that results in a reward, then dopamine would be released and the A/B connection would be ...

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Schizophrenia, Dopamine and the Striatum: From Biology to ...

Schizophrenia, Dopamine and the Striatum: From Biology to ...

Dopamine and the Striatum: From Biology to Symptoms Robert A. McCutcheon,1,2,3,4 Anissa Abi-Dargham,5 and Oliver D. Howes1,2,3,4,* The mesolimbic hypothesis has been a central dogma of schizophrenia for decades, positing that aberrantfunctioning ofmidbraindopamine projections to limbic regions causes psychotic symptoms. Recently, however, advances in neuroimaging techniques have led to the ...

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Evolution and cell biology of dopamine receptors in ...

Evolution and cell biology of dopamine receptors in ...

Hypothesis on the evolution of dopamine receptors drawn from the phylogenetic analysis is shown on the right part of the figure. Two steps of gene duplications (1 and 2 in the figure), which occurred between the divergence of jawless vertebrates (agnathans) and the emergence of jawed vertebrates (gnathostomes), generated the four D 1 receptor paralogues (see text for details).Although it is ...

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