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of depression in >9,000 depression, psycho-oncology, psychoneuroimmunology, patients, each in a variety of settings and ages, calculated the prevalence as 10.8% and 12.9%, respectively. In addition, a further 16% of patients are reported to have subclinical, yet still damaging, depression (2,5). Depression in cancer patients: Pathogenesis, implications and treatment (Review) HAMISH R. SMITH ...
Continue Reading...The Role of Interleukin-1 in the Pathogenesis of Cancer and its Potential as a Therapeutic Target in Clinical Practice Adi Litmanovich. Khaled Khazim. Idan Cohen To view enhanced content go to www.oncologytherapy-open.com Received: September 30, 2018/Published online: November 28, 2018 The Author(s) 2018 ABSTRACT Interleukin-1 (IL-1) has long been known to be a key mediator of immunity and ...
Continue Reading...2 1 Ubiquitin Signaling and Cancer Pathogenesis Fig. 1.1. Ubiquitin and ubiquitin - like protein (Ubl) modi? cations regulate a wide variety of cellular processes. Ubiquitin and Ubls share the same ubiquitin superfold and are collectively referred to as ubiquitons. All ubiquitons are attached via their C - terminal
Continue Reading...variety of cell behaviors, including proliferation, apopto-sis, and response to normal bacterial microflora (20). Altered glycosylation patterns are detected in many types of cancer and may play a role in cancer pathogenesis. Although not thoroughly understood, the aberrant exp-ression pattern of glycosyltransferases and glycosidases within the endoplasmic reticulum and Golgi apparatus of ...
Continue Reading...ABSTRACT Major advances in our understanding of cancer pathogenesis and therapy have come from efforts to catalog genomic alterations in cancer. A growing number of large-scale genomic studies have uncovered mutations that drive cancer by perturbing cotranscrip-tional and post-transcriptional regulation of gene expression. These include alterations that affect each phase of RNA processing ...
Continue Reading...From pathogenesis to clinical application: insights into exosomes as transfer vectors in cancer Wenting Xu, Zhen Yang* and Nonghua Lu* Abstract Exosomes are nanoscale extracellular membrane vesicles that are created by the fusion of an intracellular multivesicular body with the cell membrane. They are widely distributed in serum, urine, saliva and other biological fluids. As important transfer ...
Continue Reading...Thirty thousand patients are diagnosed with small cell lung cancer (SCLC) in the United States each year. SCLC has a unique natu-ral history with a shorter doubling time, higher growth fraction, earlier development of widespread metastases, and uniform initial response to chemotherapy and radiation. First-line treatment for SCLC involves combination chemotherapy with cisplatin or car-boplatin ...
Continue Reading...Unraveling the pathogenesis of cancer has not only helped us understand how a cell transforms into a tumor but has also promoted molecular tests that now help diagnose and provide prognoses for a variety of cancers in humans and animals. Genetic injury Genetic damage is a universal component of the pathogenesis of neoplasia, with somatic mutations in genes identified in 90% of cases, and germ ...
Continue Reading...Embajada de Colombia en los Países Bajos, y trece periodistas de nueve países europeos. Luego de la llegada del Boeing 777-200 al aeropuerto El Dorado, se realizó una ceremonia con diferentes autoridades, incluyendo a la Viceministra de Turismo Sandra Howard y el Vicepresidente de Promoción de Turismo de Procolombia, Enrique Stellabatti. Durante la estadía del grupo en Bogotá y Cali, se ...
Continue Reading...La embajada de Países Bajos en la ciudad de Bogotá fue el escenario en el cual se presentó el proyecto que contempla la creación de laboratorios vivientes en el Parque El Vergel, el Salado de Consotá y el Jardín Botánico de la UTP, escalable al Batallón San Mateo. Además la Universidad Tecnológica presentó el proyecto Campus Sostenible UTP que se convertirá en un gran referente ...
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